| 產(chǎn)品編號(hào) | bsm-61287R |
| 英文名稱(chēng) | ILK Recombinant Rabbit mAb |
| 中文名稱(chēng) | 整合素連接激酶ILK重組兔單抗 |
| 別 名 | ILK; DKFZp686F1765; P59; ILK1; Integrin linked protein kinas. |
| 抗體來(lái)源 | Rabbit |
| 克隆類(lèi)型 | Recombinant |
| 克 隆 號(hào) | 10G2 |
| 交叉反應(yīng) | Human,Mouse,Rat |
| 產(chǎn)品應(yīng)用 | WB=1:500-2000,Flow-Cyt=1:20-50,ICC/IF=1:50-200,IP=1:20-50
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 51 kDa |
| 檢測(cè)分子量 | 51 |
| 性 狀 | Liquid |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human ILK |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol. |
| 保存條件 | Store at 4℃ for short term. Store at -20℃ for long term. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
Integrin-linked kinases (ILKs) couple integrins and growth factors to downstream pathways involved in cell survival, cell cycle control, cell-cell adhesion and cell motility. ILK functions as a scaffold bridging the extracellular matrix (ECM) and growth factor receptors to the actin cytoskeleton through interactions with integrin, PINCH (which links ILK to the RTKs via Nck2), CH-ILKBP and affixin. SWISS: Q13418 Gene ID: 3611 ILK 是一種新發(fā)現(xiàn)的Ser/Thr蛋白激酶。ILK能夠通過(guò)與整合素β1亞單位的結(jié)合介導(dǎo)細(xì)胞與胞外基質(zhì)的連接，以依賴(lài)于PI3K的方式激活，并通過(guò)磷酸化下游底物PKB/AKT,GSK3等胞外信號(hào)的一項(xiàng)下游傳遞，對(duì)細(xì)胞的生長(zhǎng)，分化，遷移等進(jìn)行調(diào)控。由于ILK在胞內(nèi)外信號(hào)傳導(dǎo)中起著重要的作用。并且抑制ILK的活性能夠?qū)е录?xì)胞周期的停滯和細(xì)胞程序性死亡的啟動(dòng)，使其成為腫瘤治療和腫瘤藥物的理想靶位點(diǎn)。 |
| 產(chǎn)品圖片 |
25 ug total protein per lane of various lysates (see on figure) probed with ILK monoclonal antibody, unconjugated (bsm-61287R) at 1:2000 dilution and 4°C overnight incubation. Followed by conjugated secondary antibody incubation at r.t. for 60 min.
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