產(chǎn)品編號 | bsm-61403R |
英文名稱 | AAT Recombinant Rabbit mAb |
中文名稱 | α-1抗胰蛋白酶重組兔單抗 |
別 名 | Serpin A1; Short peptide from AAT; SPAAT; AAT. |
抗體來源 | Rabbit |
克隆類型 | Recombinant |
交叉反應(yīng) | Human |
產(chǎn)品應(yīng)用 | WB=1:1000-1:2000,ICC/IF=1:50-1:200,IP=1:20-1:50
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
理論分子量 | 47 kDa |
檢測分子量 | 51 |
性 狀 | Liquid |
免 疫 原 | KLH conjugated synthetic peptide derived from human Antithrombin 3 |
亞 型 | IgG |
純化方法 | affinity purified by Protein A |
緩 沖 液 | 10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol. |
保存條件 | Store at 4℃ for short term. Store at -20℃ for long term. Avoid repeated freeze/thaw cycles. |
注意事項 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
PubMed | PubMed |
產(chǎn)品介紹 |
Inhibitor of serine proteases. Its primary target is elastase, but it also has a moderate affinity for plasmin and thrombin. Irreversibly inhibits trypsin, chymotrypsin and plasminogen activator. The aberrant form inhibits insulin-induced NO synthesis in platelets, decreases coagulation time and has proteolytic activity against insulin and plasmin. SWISS: P01009 Gene ID: 5265 α1-抗胰蛋白酶(A1AT)缺乏是最常見的遺傳代謝病,能引起肺和肝的損傷。α1抗胰蛋白酶為呼吸系統(tǒng)的非特異性可溶因子,與呼吸道抵抗力關(guān)系密切,它可抑制多種酶的活性,包括細菌的酶,以及中性白細胞溶酶體分泌的蛋白酶、彈性蛋白酶、膠原酶、纖維蛋白溶酶和凝血酶。α1抗胰蛋白酶的缺乏與慢性阻塞性肺病的形成關(guān)系密切,因為它的缺乏,不能及時控制感染和炎癥產(chǎn)生的多種蛋白酶,而造成肺組織破壞。 α1-抗胰蛋白酶由肝細胞產(chǎn)生,是一種分子量為45-56kDa的糖蛋白,它能抑制蛋白酶、彈性蛋白酶、膠原酶等多種水解酶的活性。 |
產(chǎn)品圖片 | |
1、抗體溶解方法 | |
2、抗體修復(fù)方式 | |
3、常用試劑的配制 | |
4、免疫組化操作步驟 | |
5、免疫組化問題解答 | |
6、Western Blotting 操作步驟 | |
7、Western Blotting 問題解答 | |
8、關(guān)于肽鏈的設(shè)計 | |
9、多肽的溶解與保存 | |
10、酶標抗體效價測定程序 | |