| 產(chǎn)品編號(hào) | bsm-61410R |
| 英文名稱 | NUMB Recombinant Rabbit mAb |
| 中文名稱 | 膜相關(guān)蛋白Numb重組兔單抗 |
| 別 名 | c14_5527; h Numb; Numb; Numb homolog; S171. |
| 抗體來源 | Rabbit |
| 克隆類型 | Recombinant |
| 交叉反應(yīng) | Human,Mouse,Rat |
| 產(chǎn)品應(yīng)用 | WB=1:1000-1:2000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 71 kDa |
| 檢測(cè)分子量 | 71 |
| 性 狀 | Liquid |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human NUMB |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol. |
| 保存條件 | Store at 4℃ for short term. Store at -20℃ for long term. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
Numb acts as a negative regulator of Notch signaling by promoting ubiquitination and degradation of Notch. The protein is asymmetrically segregated into one daughter cell during cell division, producing two daughter cells with different responses to Notch signaling and different cell fates. The localization of Numb can also be regulated by G-protein coupled receptor (GPCR) and PKC signaling. SWISS: P49757 Gene ID: 8650 膜相關(guān)蛋白Numb是細(xì)胞命運(yùn)決定因子：在細(xì)胞有絲分裂期，Numb選擇性地分布于細(xì)胞的一側(cè),在胞質(zhì)分裂后則被分配于一個(gè)子細(xì)胞，Numb通過抑制跨膜受體Notch而發(fā)揮作用, Numb信號(hào)途徑在前體細(xì)胞的神經(jīng)元調(diào)控方面起著重要作用. |
| 產(chǎn)品圖片 |
Western blot analysis of Ramos cell lysate. Using NUMB (bsm-61410R) monoclonal antibody at 1:1000 dilution and 4°C overnight incubation. Followed by conjugated secondary antibody incubation at r.t. for 60 min.
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