| 產(chǎn)品編號(hào) | bsm-61422R |
| 英文名稱 | CTCF Recombinant Rabbit mAb |
| 中文名稱 | 轉(zhuǎn)錄阻抑蛋白CTCF重組兔單抗 |
| 別 名 | Ctcf; CTCFL paralog; MRD21. |
| 抗體來源 | Rabbit |
| 克隆類型 | Recombinant |
| 交叉反應(yīng) | Human,Mouse,Rat |
| 產(chǎn)品應(yīng)用 | WB=1:500-2000,IHC-P=1:50-200,IHC-F=1:50-200,IF=1:50-200,Flow-Cyt=1:20-50,ICC/IF=1:50-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 83 kDa |
| 檢測(cè)分子量 | 140 |
| 性 狀 | Liquid |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human CTCF |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol. |
| 保存條件 | Store at 4℃ for short term. Store at -20℃ for long term. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
Plays a important role in chromatin remodeling. Can dimerize when it is bound to different DNA sequences, mediating long-range chromatin looping. Mediates interchromosomal association between IGF2/H19 and WSB1/NF1 and may direct distant DNA segments to a common transcription factory. SWISS: P49711 Gene ID: 10664 CTCF是一種結(jié)構(gòu)保守、功能多樣的鋅指蛋白。通過不同鋅指的組合，識(shí)別不同的DNA序列，并且通過自身形成多聚體或與其它蛋白相互作用、與亞細(xì)胞核結(jié)構(gòu)共定位等多種方式，在基因活化與沉默、基因印記、X-染色體失活以及基因組核內(nèi)空間組織等不同生理過程中發(fā)揮關(guān)鍵作用。CTCF在細(xì)胞生長(zhǎng)與增殖、系統(tǒng)發(fā)生以及腫瘤發(fā)生等方面都有著重要的作用。 |
| 產(chǎn)品圖片 |
Western blot analysis of (1) HeLa cell lysate; (2) Mouse brain lysate. Using CTCF (bsm-61422R) monoclonal antibody at 1:1000 dilution and 4°C overnight incubation. Followed by conjugated secondary antibody incubation at r.t. for 60 min.
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