| 產(chǎn)品編號(hào) | bsm-61456R |
| 英文名稱 | Hepcidin-25 Recombinant Rabbit mAb |
| 中文名稱 | 鐵調(diào)節(jié)蛋白25重組兔單抗 |
| 別 名 | Hepcidin; Liver-expressed antimicrobial peptide 1; LEAP-1; Putative liver tumor regressor; PLTR; Hepcidin-25; Hepc25; Hepcidin-20; Hepc20; HAMP; HEPC; LEAP1. |
| 抗體來源 | Rabbit |
| 克隆類型 | Recombinant |
| 克 隆 號(hào) | |
| 交叉反應(yīng) | Human,Rat |
| 產(chǎn)品應(yīng)用 | WB=1:500-2000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 9 kDa |
| 檢測(cè)分子量 | 25 |
| 性 狀 | Liquid |
| 免 疫 原 | A synthesized peptide derived from human Hepcidin: 1-84/84 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol. |
| 保存條件 | Store at 4℃ for short term. Store at -20℃ for long term. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
Hepcidin, also known as HAMP, HEPC, LEAP1 or HFE2B, is an 84 amino acid secreted protein that regulates iron-related signaling events. Acts by promoting endocytosis and degradation of ferroportin, leading to the retention of iron in iron-exporting cells and decreased flow of iron into plasma. SWISS: P81172 Gene ID: 57817 Hepcidin是一種由肝臟細(xì)胞產(chǎn)生的具有廣譜殺菌抑菌作用的抗菌肽，屬于防御性蛋白家族。Hepcidin在肝臟合成時(shí)，首先產(chǎn)生一種早期多肽，由84個(gè)氨基酸殘基組成。在其Gly24和Ser25之間存在一個(gè)酶切位點(diǎn)，當(dāng)酶切去除其24個(gè)氨基酸殘基的信號(hào)肽后，形成由60個(gè)氨基酸殘基組成的前體肽(pro-Hepcidin)，并通過轉(zhuǎn)運(yùn)進(jìn)入血液循環(huán)，最后由前肽轉(zhuǎn)化酶(propeptide convertase)在N端的不同位點(diǎn)剪接生成3種不同的成熟小肽，分別由20、22、25個(gè)氨基酸組成，其中以25個(gè)氨基酸為其主要形 |
| 產(chǎn)品圖片 |
Western blot analysis of Human Hepcidin Full-length Recombinant Protein (GFP Tagged). Using Hepcidin-25 (bsm-61456R) monoclonal antibody at 1:1000 dilution and 4°C overnight incubation. Followed by conjugated secondary antibody incubation at r.t. for 60 min.
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