| 產(chǎn)品編號(hào) | bs-11834R |
| 英文名稱 | DYRK1A Rabbit pAb |
| 中文名稱 | 絲氨酸/蘇氨酸蛋白激酶MNB抗體 |
| 別 名 | Dual specificity tyrosine phosphorylation regulated kinase 1A; DYRK 1; DYRK 1A; DYRK; DYRK1; DYRKA; HP 86; HP86; Minibrain(Drosophila) homolog; Minibrain homolog; MNB; MNB/DYRK protein kinase antibody; MNBH; Protein kinase minibrain homolog; Serine/threon |
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Specific References (1) | bs-11834R has been referenced in 1 publications.
[IF=5.273] Xin Liu. et al. An inhibitor with GSK3β and DYRK1A dual inhibitory properties reduces Tau hyperphosphorylation and ameliorates disease in models of Alzheimer's disease. NEUROPHARMACOLOGY. 2023 Jul;232:109525 WB ; Human.
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| 研究領(lǐng)域 | 神經(jīng)生物學(xué) 激酶和磷酸酶 |
| 抗體來(lái)源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | (predicted: Human,Mouse,Rat,Rabbit,Pig,Sheep,Cow,Chicken,Dog,Horse) |
| 產(chǎn)品應(yīng)用 | WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ICC/IF=1:100-500,ELISA=1:5000-10000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 86 kDa |
| 檢測(cè)分子量 | |
| 細(xì)胞定位 | 細(xì)胞核 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human DYRK1A: 81-170/763 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
Dyrk (for dual specificity tyrosine phosphorylation regulated kinase) is the homolog of the Drosophila mnb (minibrain) gene which is required for neurogenesis. Dyrk is a dual-specificity tyrosine kinase and serine/threonine kinase, which is itself regulated by tyrosine phosphorylation. Several mammalian Dyrk related proteins have been identified and are thought to compose a family of dual specificity protein kinases. Dyrk family members, including Dyrk1A (dual specificity tyrosine-phosphorylation-regulated kinase 1A), Dyrk1B, Dyrk1C, Dyrk2, Dyrk3, Dyrk4A and Dyrk4B, are thought to be involved in diverse cellular functions. Localized to the nucleus and highly expressed in testis, muscle and the developing nervous system, Dyrk1A, also known as MNB or MNBH, functions to phosphorylate serine, threonine and tyrosine residues on various substrates involved in signaling pathways that regulate cell proliferation. Dyrk1A is a candidate gene for learning defects that are involved in Downs syndrome (DS), suggesting a possible role for Dyrk1A in the development of DS. Four isoforms of Dyrk1A exist due to alternative splicing events. Function: DYRK1A, the vertebrate of Drosophilia Minibrain, is a dual-specificity kinase predominately expressed in the central nervous system. The human clone has been isolated from the Downs' syndrome critical region and it is potentially implicated in the neuropathology of the disease. Main features of the protein include an N-terminal nuclear translocation signal, a putative leucine zipper domain, a core kinase domain with some similarity to kinases involved in cell cycle regulation and a C-terminal PEST sequence. The DYRK1A kinase can be phosphorylated on tyrosine residues, leading to an active kinase that can phosphorylated itself or exogenous substrates on both tyrosine and serine/threonine residues. DYRK1A can also multimerize and translocate to the nucleus. Present studies on DYRK1A suggest a potential role for this kinase in the exit from the cell cycle and the beginning of neuronal differentiation. Subunit: Interacts RAD54L2/ARIP4 (By similarity). Interacts with RANBP9. Interacts with WDR68. Subcellular Location: Nucleus speckle. Tissue Specificity: Ubiquitous. Highest levels in skeletal muscle, testis, fetal lung and fetal kidney. Post-translational modifications: Autophosphorylated on tyrosine residues. DISEASE: Defects in DYRK1A are the cause of mental retardation autosomal dominant type 7 (MRD7) [MIM:614104]. A disease characterized by primary microcephaly, severe mental retardation without speech, anxious autistic behavior, and dysmorphic features, including bitemporal narrowing, deep-set eyes, large simple ears, and a pointed nasal tip. Mental retardation is characterized by significantly below average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. [SIMILARITY] Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily. Similarity: Contains 1 protein kinase domain. SWISS: Q13627 Gene ID: 1859 Database links: Entrez Gene: 1859 Human Entrez Gene: 13548 Mouse Omim: 600855 Human SwissProt: Q13627 Human SwissProt: Q61214 Mouse Unigene: 368240 Human Unigene: 310973 Mouse Unigene: 9354 Rat |
