| 產(chǎn)品編號 | bs-18202R |
| 英文名稱 | LD78 beta/CCL3L1 Rabbit pAb |
| 中文名稱 | 巨噬細(xì)胞炎性蛋白3樣蛋白1抗體 |
| 別 名 | 464.2; C C motif chemokine 3 like 1; CCL3L1; CCL3L3; Chemokine(C C motif) ligand 3 like 1; Chemokine(C C motif) ligand 3 like 3; Chemokine(C C motif) ligand 3 like, centromeric; chemokine(CC motif) ligand 3 like 1; CL3L1_HUMAN; D17S1718; G0/G1 switch regulatory protein 19-2; G0S19-2; LD78; LD78 beta(1-70); LD78-beta(1-70); LD78-beta(5-70); LD78BETA; MGC104178; MGC12815; MGC182017; MIP1AP; PAT 464.2; SCYA3L; SCYA3L1; Small inducible cytokine A3 like 1 precursor; Small-inducible cytokine A3-like 1; Tonsillar lymphocyte LD78 beta; Tonsillar lymphocyte LD78 beta protein. |
| 研究領(lǐng)域 | 細(xì)胞生物 免疫學(xué) 信號轉(zhuǎn)導(dǎo) |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 克 隆 號 | |
| 交叉反應(yīng) | (predicted: Human,Recombinant Fragment) |
| 產(chǎn)品應(yīng)用 | IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ICC/IF=1:100-500
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 8 kDa |
| 檢測分子量 | |
| 細(xì)胞定位 | 分泌型蛋白 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human LD78 beta/CCL3L1: 31-93/93 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
This gene is one of several cytokine genes that are clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins that function in inflammatory and immunoregulatory processes. The protein encoded by this gene binds to several chemokine receptors, including chemokine binding protein 2 and chemokine (C-C motif) receptor 5 (CCR5). CCR5 is a co-receptor for HIV, and binding of this protein to CCR5 inhibits HIV entry. The copy number of this gene varies among individuals, where most individuals have one to six copies, and a minority of individuals have zero or more than six copies. There are conflicting reports about copy number variation of this gene and its correlation to disease susceptibility.[provided by RefSeq, Apr 2014] Function: Chemotactic for lymphocytes and monocytes. Is a ligand for CCR1, CCR3 and CCR5. Is an inhibitor of HIV-1-infection. The processed form LD78-beta(3-70) shows a 20-fold to 30-fold higher chemotactic activity and is a very potent inhibitor of HIV-1-infection. LD78-beta(3-70) is also a ligand for CCR1, CCR3 and CCR5. Subcellular Location: Secreted. Post-translational modifications: The N-terminal processed forms LD78-beta(3-70) and LD78-beta(5-70) are produced by proteolytic cleavage after secretion from peripheral blood monocytes. The cleavage to yield LD78-beta(3-70) is probably achieved by DPP4. Similarity: Belongs to the intercrine beta (chemokine CC) family. SWISS: P16619 Gene ID: 6349 Database links: Entrez Gene: 414062 Human Entrez Gene: 6349 Human Omim: 601395 Human Omim: 609468 Human SwissProt: P16619 Human Unigene: 512304 Human Unigene: 512683 Human |
