| 產(chǎn)品編號(hào) | bs-23915R |
| 英文名稱 | MUC5B Rabbit pAb |
| 中文名稱 | 粘蛋白-5B抗體 |
| 別 名 | High molecular weight salivary mucin MG1; MUC5; Mucin 5 subtype B, tracheobronchial; Mucin 5B; Sublingual gland mucin; 2300002I04Rik; A130042M24; AV085033; Cervical mucin; Cervical mucin MUC5B; High molecular weight salivary mucin MG1; MUC-5B; MUC5B; MUC5 |
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Specific References (2) | bs-23915R has been referenced in 2 publications.
[IF=7.901] Zeng Z et al. Stimuli-Responsive Self-assembled Dendrimers for Oral Protein Delivery. J Control Release. 2019 Oct 28;315:206-213. ICF ; Human.
[IF=7.727] Xue Wang. et al. Engineered liposomes targeting the gut–CNS Axis for comprehensive therapy of spinal cord injury. J Control Release. 2021 Mar;331:390 IF ; Human.
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| 研究領(lǐng)域 | 細(xì)胞生物 信號(hào)轉(zhuǎn)導(dǎo) 細(xì)胞骨架 |
| 抗體來(lái)源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Rat (predicted: Human,Mouse) |
| 產(chǎn)品應(yīng)用 | IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 630 kDa |
| 檢測(cè)分子量 | |
| 細(xì)胞定位 | 分泌型蛋白 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/1ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human MUC5B: 1151-1250/5763 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
Tumor Markers Mucins are high molecular mass, highly glycosylated macromolecules that are the major components of mucus secretions. MUC5B is a salivary mucin that is thought to contribute to the lubricating and viscoelastic properties of whole saliva. It is composed of 14.9% protein, 78.1% carbohydrate, and 7% sulfate (Troxler et al., 1995 [PubMed 8554565]).[supplied by OMIM] Function: Gel-forming mucin that is thought to contribute to the lubricating and viscoelastic properties of whole saliva and cervical mucus. Subcellular Location: Secreted. Tissue Specificity: Expressed on surface airway epithelia. Expressed mainly in mucous cells of submucosal glands of airway tissues. Highly expressed in the sublingual gland. Also found in submaxillary glands, endocervix, gall bladder, and pancreas. Post-translational modifications: Highly glycosylated. C-, N- and O-glycosylated. C-mannosylated in the Cys-rich subdomains probably on the first Trp residue of the WXXW motif. Highly O-glycosylated in the Ser/Thr-rich tandem repeat (TR) region. The repeat region is about 59% O-glycosylated with a high abundance of NeuAc(2)Hex(1)HexNac1-ol. Similarity: Contains 1 CTCK (C-terminal cystine knot-like) domain. Contains 3 HAT repeats. Contains 3 TIL (trypsin inhibitory-like) domains. Contains 3 VWFC domains. Contains 4 VWFD domains. SWISS: Q9HC84 Gene ID: 727897 Database links: Entrez Gene: 727897 Human Omim: 600770 Human SwissProt: Q9HC84 Human Unigene: 523395 Human |
| 產(chǎn)品圖片 |
Paraformaldehyde-fixed, paraffin embedded (Rat pancreas); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (MUC5B) Polyclonal Antibody, Unconjugated (bs-23915R) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.
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