| 產(chǎn)品編號(hào) | bsm-60755R |
| 英文名稱 | KCNJ6 Recombinant Rabbit mAb |
| 中文名稱 | G蛋白激活內(nèi)流鉀通道蛋白2重組兔單克隆抗體 |
| 別 名 | IRK6_HUMAN; G protein-activated inward rectifier potassium channel 2; GIRK2; KATP2; KATP-2; KCNJ7; GIRK-2; BIR1; KPLBS; KIR3.2; hiGIRK2; Inward rectifier K(+) channel Kir3.2; Potassium channel, inwardly rectifying subfamily J member 6; potassium inwardly |
| 抗體來(lái)源 | Rabbit |
| 克隆類型 | Recombinant |
| 交叉反應(yīng) | Mouse |
| 產(chǎn)品應(yīng)用 | WB=1:500-2000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 47 kDa |
| 檢測(cè)分子量 | |
| 細(xì)胞定位 | 細(xì)胞膜 |
| 性 狀 | Lyophilized or Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from mouse KCNJ6 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | PBS, Glycerol, BSA. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
This gene encodes a member of the G protein-coupled inwardly-rectifying potassium channel family of inward rectifier potassium channels. This type of potassium channel allows a greater flow of potassium into the cell than out of it. These proteins modulate many physiological processes, including heart rate in cardiac cells and circuit activity in neuronal cells, through G-protein coupled receptor stimulation. Mutations in this gene are associated with Keppen-Lubinsky Syndrome, a rare condition characterized by severe developmental delay, facial dysmorphism, and intellectual disability. [provided by RefSeq, Apr 2015] Function: This potassium channel may be involved in the regulation of insulin secretion by glucose and/or neurotransmitters acting through G-protein-coupled receptors. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Subunit: Associates with GIRK1 or GIRK4 to form a G-protein-activated heteromultimer pore-forming unit. The resulting inward current is much larger. Subcellular Location: Membrane; Multi-pass membrane protein. Tissue Specificity: Most abundant in cerebellum, and to a lesser degree in islets and exocrine pancreas. Similarity: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ6 subfamily. SWISS: P48542 Gene ID: 16522 Database links: Entrez Gene: 3763 Human Entrez Gene: 16522 Mouse SwissProt: P48051 Human SwissProt: P48542 Mouse |
| 產(chǎn)品圖片 |
Sealing solution and concentration: 5% NFDM/TBST
Dilution ratio of primary antibody: 1:5000
Incubation conditions for primary antibody: 2 hours at room temperature
Secondary antibody: Goat Anti Rabbit IgG H&L (HRP)
Cracking solution: 1: Mouse liver (negative control), 2: Mouse brain
Protein loading amount: 20 μ g
Exposure time: 60 seconds
Theoretical molecular weight: 48 kDa
Actual molecular weight: 40, 48 kDa
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