| 產(chǎn)品編號 | bsm-54127R |
| 英文名稱 | TXNIP Recombinant Rabbit mAb |
| 中文名稱 | 硫氧還蛋白結(jié)合蛋白2重組兔單抗 |
| 別 名 | THIF; thioredoxin binding protein 2; thioredoxin interacting protein; Thioredoxin-binding protein 2; Thioredoxin-interacting protein; upregulated by 1, 25-dihydroxyvitamin D-3; VDUP1; Vitamin D3 up-regulated protein 1; TXNIP_HUMAN. |
| 抗體來源 | Rabbit |
| 克隆類型 | Recombinant |
| 克 隆 號 | 8A11 |
| 交叉反應(yīng) | Human (predicted: Mouse,Rat) |
| 產(chǎn)品應(yīng)用 | WB=1:500-2000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 44 kDa |
| 檢測分子量 | |
| 細(xì)胞定位 | 細(xì)胞核 細(xì)胞漿 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human TXNIP |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.02% Proclin300. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
TXNIP may act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability. It interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm. It functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and corepressor complexes, and over-expression will induce G0/G1 cell cycle arrest. It is required for the maturation of natural killer cells (from SwissProt). Function: May act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability. Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm. Functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and corepressor complexes, and over-expression will induce G0/G1 cell cycle arrest. Required for the maturation of natural killer cells. Acts as a suppressor of tumor cell growth. Inhibits the proteasomal degradation of DDIT4, and thereby contributes to the inhibition of the mammalian target of rapamycin complex 1 (mTORC1). Subunit: Interacts with TXN/thioredoxin through its redox-active site. Interacts with transcriptional repressors ZBTB16, ZBTB32 and HDAC1. Interacts (via C-terminus) with ITCH (via WW domains). Interacts with DDIT4. Subcellular Location: Cytoplasm Post-translational modifications: Ubiquitinated; undergoes polyubiquitination catalyzed by ITCH resulting in proteasomal degradation. Similarity: Belongs to the arrestin family. SWISS: Q9H3M7 Gene ID: 10628 Database links: UniProtKB/Swiss-Prot: Q9H3M7.1 硫氧還蛋白結(jié)合蛋白-2 (TRX-binding protein-2，TBP-2)又稱:維生素D3上調(diào)蛋白1(Vitamin D3 up-regulated protein 1，VDUP1)或稱硫氧還蛋白相互作用蛋白(Thioredoxin-interacting protein，Txnip)。 TBP-2與硫氧還蛋白(thioredoxin，TRX)的活性部位結(jié)合，抑制其活性，除了參與多種氧化應(yīng)激反應(yīng)，還具有多種生物學(xué)功能。 有學(xué)者認(rèn)為：TBP-2與腫瘤密切相關(guān)，有些腫瘤組織中，TBP-2表達(dá)降低或缺失。TBP-2表達(dá)增高時，細(xì)胞周期停滯，腫瘤細(xì)胞繁殖受到抑制。目前已成為腫瘤研究的重要靶點。 |
| 產(chǎn)品圖片 |
Sample:
Lane 1: Human MCF-7 cell lysates
Lane 2: Human HeLa cell lysates
Primary: Anti-TXNIP (bsm-54127R) at 1/500 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 44 kDa
Observed band size: 53 kDa
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