| 產(chǎn)品編號(hào) | bsm-61002R |
| 英文名稱 | GABARAPL2 Recombinant Rabbit mAb |
| 中文名稱 | G1氨基丁酸A型受體相似蛋白2重組兔單抗 |
| 別 名 | ATG 8; ATG8; FLC 3A; FLC3A; GABA(A) receptor associated protein like 2; gamma aminobutyric acid receptor associated protein like 2; Ganglioside expression factor 2; GATE 16; GATE16; General protein transport factor p16; MAP1 light chain 3 related protein; |
| 抗體來(lái)源 | Rabbit |
| 克隆類型 | Recombinant |
| 克 隆 號(hào) | 14D2 |
| 交叉反應(yīng) | Human,Mouse,Rat |
| 產(chǎn)品應(yīng)用 | WB=1:500-2000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 14 kDa |
| 檢測(cè)分子量 | |
| 細(xì)胞定位 | 細(xì)胞漿 |
| 性 狀 | Liquid |
| 濃 度 | 1m/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human GABARAPL2 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
In the central nervous system GABA functions as the main inhibitory transmitter by increasing a Cl-conductance that inhibits neuronal firing (1). GABA has been shown to activate both ionotropic (GABAA) and metabotropic (GABAB) receptors as well as a third class of receptors called GABAC (2,3). In addition to GABA receptors, several proteins have been identified as regulators of GABA function, including GAD65, GAD67, GABA transporters and GABARAP (GABAA receptor-associated protein) (4-6). GABARAP associates with GABAA Rg2 to link GABAA receptors to the cytoskeleton (6). The GABARAP protein sequence is similar to light chain-3 of microtubule-associated proteins (MAPs) suggesting that it may be a type of MAP or a component of a MAP complex (6). Function: Involved in intra-Golgi traffic. Modulates intra-Golgi transport through coupling between NSF activity and SNAREs activation. It first stimulates the ATPase activity of NSF which in turn stimulates the association with GOSR1. Subcellular Location: Golgi apparatus. Tissue Specificity: Ubiquitous. Expressed at high levels in the brain, heart, prostate, ovary, spleen and skeletal muscle. Expressed at very low levels in lung, thymus and small intestine. Post-translational modifications: Phosphorylated upon DNA damage, probably by ATM or ATR. Similarity: Belongs to the MAP1 LC3 family. Database links: Entrez Gene: 11345 Human Entrez Gene: 93739 Mouse Omim: 607452 Human SwissProt: P60520 Human SwissProt: P60521 Mouse Unigene: 461379 Human Unigene: 371666 Mouse Unigene: 120952 Rat Unigene: 64537 Rat GABAA受體相關(guān)蛋白相似蛋白2；GABA受體A型相關(guān)蛋白樣2 |
| 產(chǎn)品圖片 |
25 ug total protein per lane of various lysates (see on figure) probed with GABARAPL2 monoclonal antibody, unconjugated (bsm-61002R) at 1:500 dilution and 4°C overnight incubation. Followed by conjugated secondary antibody incubation at r.t. for 60 min.
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