| 產(chǎn)品編號(hào) | bsm-55521R |
| 英文名稱 | Phospho-JNK (T183/Y185) Recombinant Rabbit mAb |
| 中文名稱 | 磷酸化氨基末端激酶重組兔單抗 |
| 別 名 | JNK1+JNK2+JNK3, JNK1/2/3, JNK1+2+3, MAPK8, MAPK9, MAPK10, c Jun N terminal kinase 1, c Jun N terminal kinase 2, c Jun N terminal kinase 3, P-JNK0 |
| 抗體來源 | Rabbit |
| 克隆類型 | Recombinant |
| 克 隆 號(hào) | SB97 |
| 交叉反應(yīng) | Human,Mouse,Rat |
| 產(chǎn)品應(yīng)用 | WB=1: 100-500
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 46/54 kDa |
| 檢測(cè)分子量 | 46/54 |
| 性 狀 | Liquid |
| 免 疫 原 | KLH conjugated Synthetic phosphopeptide derived from Human JNK(T183/Y185) |
| 亞 型 | IgG |
| 純化方法 | Affinity Purification |
| 緩 沖 液 | PBS with 100 μg/ml BSA,0.15% ProClin300 and 50% glycerol. |
| 保存條件 | Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase targets specific transcription factors, and thus mediates immediate-early gene expression in response to various cell stimuli. It is most closely related to MAPK8, both of which are involved in UV radiation induced apoptosis, thought to be related to the cytochrome c-mediated cell death pathway. This gene and MAPK8 are also known as c-Jun N-terminal kinases. SWISS: P45983 Gene ID: 5599 絲氨酸/蘇氨酸蛋白激酶參與多種過程，如細(xì)胞增殖、分化、遷移、轉(zhuǎn)化和程序性細(xì)胞死亡。細(xì)胞外刺激如促炎細(xì)胞因子或物理應(yīng)激刺激應(yīng)激激活的蛋白激酶/c-Jun N-末端激酶（SAP/JNK）信號(hào)通路。應(yīng)激激活的蛋白激酶/Jun氨基末端激酶SAPK/JNK可有效、優(yōu)先被各種環(huán)境應(yīng)激被激活，這些應(yīng)激反應(yīng)包括紫外線和γ輻射、神經(jīng)酰胺和炎性細(xì)胞因子，以及生長(zhǎng)因子和GPCR激動(dòng)劑（在某些情況下）。與其它MAPK一樣，核心信號(hào)轉(zhuǎn)導(dǎo)單元由一個(gè)MAPKKK（一般為MEKK1-MEKK4），或一個(gè)能磷酸化和激活MKK4/7的混合譜 |
