| 產(chǎn)品編號 | V7901 |
| 英文名稱 | Human CD40L Mouse mAb |
| 中文名稱 | CD40L（CD154）單克隆抗體 |
| 別 名 | TNFSF5; CD 154; CD 40L; CD154 antigen; CD40 homologue; CD40 ligand; CD40LG; gp39; hCD40L; HIGM1; Hyper IgM syndrome; IGM; IMD3; Ly62; T B cell activating molecule; T cell antigen GP39; TBAM; TNF related activation protein; TNF superfamily member 5; Tnfsf |
| 克 隆 號 | 10A4 |
| 理論分子量 | 29kDa |
| 性 狀 | Liquid |
| 純 度 | >90% as determined by SDS-PAGE |
| 緩 沖 液 | 0.01M PBS(pH7.4) |
| 保存條件 | Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 產(chǎn)品介紹 |
CD40 ligand (CD40L) is a 33 kDa type II membrane glycoprotein expressed mainly on the cell surface of activated T lymphocytes, but also exists as a soluble form extracellularly. CD40L is the ligand for CD40, a member of the TNF superfamily, which is expressed on the cell surface of B cells, macrophages/monocytes, dendritic cells, vascular endothelial cells, and epithelial cells. CD40L plays an important role in B cell proliferation, antibody class switching, modulation of apoptosis in the germinal center through interaction with B cells expressing CD40, and activation of CD4+ T cells. Mutation within the CD40L gene is linked to hyper IgM syndrome, an X linked immunodeficiency disease that is characterized by elevated level of serum IgM and decreased level of other isotypes. SWISS: P29965 Gene ID: 959 CD40L也是T細(xì)胞活化的重要輔助刺激通路,不僅在調(diào)節(jié)T細(xì)胞免疫反應(yīng)中起關(guān)鍵作用,而且也在B細(xì)胞的活化、增殖、分化、抗體的分泌起重要作用。主要表達(dá)在B細(xì)胞，有抗凋亡和促生長、分化的作用。 |
